Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Subcellular organization of the cAMP signaling pathway
M Zaccolo, A Zerio, MJ Lobo, C Garland - Pharmacological reviews, 2021 - Elsevier
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling
SE Anton, C Kayser, I Maiellaro, K Nemec, J Möller… - Cell, 2022 - cell.com
G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
[HTML][HTML] Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling
The fidelity of intracellular signaling hinges on the organization of dynamic activity
architectures. Spatial compartmentation was first proposed over 30 years ago to explain how …
architectures. Spatial compartmentation was first proposed over 30 years ago to explain how …
Optical map** of cAMP signaling at the nanometer scale
Cells relay a plethora of extracellular signals to specific cellular responses by using only a
few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading …
few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading …
G protein–coupled receptor signaling: new insights define cellular nanodomains
G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …
family and are involved in the regulation of most cell functions. Most of them reside …
Nanodomain cAMP signalling in cardiac pathophysiology: potential for develo** targeted therapeutic interventions.
M Zaccolo, D Kovanich - Physiological reviews, 2024 - journals.physiology.org
3', 5'-cyclic adenosine monophosphate (cAMP) mediates the effects of sympathetic
stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in …
stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in …
When trafficking and signaling mix: How subcellular location shapes G protein‐coupled receptor activation of heterotrimeric G proteins
BT Lobingier, M von Zastrow - Traffic, 2019 - Wiley Online Library
G protein‐coupled receptors (GPCRs) physically connect extracellular information with
intracellular signal propagation. Membrane trafficking plays a supportive role by …
intracellular signal propagation. Membrane trafficking plays a supportive role by …
cAMP: from long-range second messenger to nanodomain signalling
N Musheshe, M Schmidt, M Zaccolo - Trends in pharmacological sciences, 2018 - cell.com
How cAMP generates hormone-specific effects has been debated for many decades.
Fluorescence resonance energy transfer (FRET)-based sensors for cAMP allow real-time …
Fluorescence resonance energy transfer (FRET)-based sensors for cAMP allow real-time …
Phosphodiesterases in heart and vessels-From Physiology to Diseases
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …