Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K3PO4-Promoted Oxidative Cyclization of Isatins at Room …

FC Jia, ZW Zhou, C Xu, YD Wu, AX Wu - Organic letters, 2016 - ACS Publications
A synergetic tert-butyl hydroperoxide/K3PO4-promoted oxidative cyclization has been
developed for the facile synthesis of various functionalized quinazolin-4 (3 H)-ones from …

Visible‐Light‐Induced Aerobic Intramolecular Cyclization of (2‐Aminophenyl)(1H‐indol‐1‐yl)methanones: Direct Access to Bioactive Tryptanthrin and its Derivatives

M Arockiaraj, G Singh, S Sree Marupalli… - Advanced Synthesis …, 2023 - Wiley Online Library
Visible‐light‐induced mild, transition metal, base, and photocatalyst‐free green protocol has
been developed for the synthesis of tryptanthrin and its derivatives. The present reaction is …

Divergent Synthesis of Methylisatoid and Tryptanthrin Derivatives by Ph3P–I2-Mediated Reaction of Isatins with and without Alcohols

M Pattarawarapan, N Wiriya… - The Journal of …, 2020 - ACS Publications
A novel phosphonium-mediated reaction of isatins is described. In the presence of alcohol,
the reaction proceeds to furnish C-12 modified tryptanthrin derivatives. Without alcohol, self …

Visible Light‐Induced Radical‐Radical Coupling: One‐Pot Synthesis of 6‐Benzyl‐6‐hydroxyindolo[2,1‐b]quinazolin‐12(6H)‐ones from Isatins and Potassium …

LQ Huang, CL Dong, YH He… - Advanced Synthesis & …, 2022 - Wiley Online Library
A method for one‐pot synthesis of 6‐benzyl‐6‐hydroxyindolo [2, 1‐b] quinazolin‐12 (6H)‐
ones from isatins and potassium benzyl trifluoroborates was developed. Bioactive …

Biological activity of quinazolinones

AA Radwan, FK Alanazi - Quinazolinone and Quinazoline …, 2020 - books.google.com
The chemical structure of quinazolinones includes benzene ring fused with 2-pyrimidinone
(1), 4-pyrimidinone (2) or 2, 4-pyrimidinedione (3) ring, and are named as quinazolin-2 (1H) …

Conversion of isatins to tryptanthrins, heterocycles endowed with a myriad of bioactivities

R Amara, H Awad, D Chaker… - European Journal of …, 2019 - Wiley Online Library
The numerous bioactivities exhibited by tryptanthrins led chemists to develop synthetic
approaches towards this important scaffold. In particular, conversion of isatins into …

Photoredox‐Catalyzed Isatin Reactions: Access to Dibenzo‐1, 7‐Naphthyridine Carboxylate and Tryptanthrin

S Sultan, V Gupta, BA Shah - ChemPhotoChem, 2017 - Wiley Online Library
A procedure for the synthesis of dibenzo‐1, 7‐naphthyridine carboxylate by means of
photoredox catalysis has been developed. The reaction features an umpolung reaction of …

Exploiting 1, 2, 3-triazolium ionic liquids for synthesis of tryptanthrin and chemoselective extraction of copper (II) ions and histidine-containing peptides

HY Li, CY Chen, HT Cheng, YH Chu - Molecules, 2016 - mdpi.com
Based on a common structural core of 4, 5, 6, 7-tetrahydro [1, 2, 3] triazolo [1, 5-a] pyridine, a
number of bicyclic triazolium ionic liquids 1–3 were designed and successfully prepared. In …

Spectro-luminescent characterization of molecular complex based on tryptanthrin for design of new effective drugs

VY Kudrya, TY Zhang, MX Tan, AP Naumenko - Journal of Luminescence, 2024 - Elsevier
Optical absorption (at room temperature), fluorescence (at room temperature and T= 78 K)
and phosphorescence (at T= 78 K) spectra of solution of the molecular complex based on …

Biocatalyst mediated synthesis of tryptanthrins performed under ultrasonication

AH Mane, AD Patil, SR Kamat, RS Salunkhe - ChemistrySelect, 2018 - Wiley Online Library
The concomitant exploitation of two of the green chemistry tools viz., sonication and
biocatalysis is reported here for the synthesis of natural alkaloid, tryptanthrin (indolo [2, 1‐b] …