Fundamental cellular operations, including DNA synthesis and the generation of ATP,
require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron …

Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

Latent HIV reservoirs are the primary hurdle to eradication of infection. Identification of
agents, pathways and molecular mechanisms that activate latent provirus may, in the …

HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its
role as the transactivator of HIV transcription is well established, other roles associated with …

HIV is a devastating human pathogen that causes serious immunological diseases in
humans around the world. The virus is able to remain latent in an infected host for many …

Retargeting of lentiviral vector entry to cell types of interest is a key factor in improving the
safety and efficacy of gene transfer. In this study we show that the retargetable envelope …

Adenosine deaminases that act on dsRNA (ADARs) are enzymes that target double-
stranded regions of RNA converting adenosines into inosines (A-to-I editing) thus …

Intron retention is a type of alternative splicing where one or more introns remain unspliced
in a polyadenylated transcript. Although many viral systems are known to translate proteins …

Considerable success has been achieved in the treatment of HIV-1 infection, and more than
two-dozen antiretroviral drugs are available targeting several distinct steps in the viral …

Although the viral Rev protein is necessary for HIV replication, its main function in the viral
replication cycle has been controversial. Reinvestigating the effect of Rev on the HIV-1 RNA …