The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties
which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely …

Alzheimer's disease (AD) is a major cause of dementia debilitating the global ageing
population. Current understanding of the AD pathophysiology implicates the aggregation of …

Lipoic acid (LA) is a versatile antioxidant to be used in various oxidation-reducing diseases
over the past 70 years. Attributing to the large five-membered ring tension, the dynamic …

Lipoic acid (LA), an endogenous small molecule in organisms, has been extensively used
for the highly efficient clinical treatment of malignant diseases, which include diabetes …

Conformational diseases are caused by the aggregation of misfolded proteins. The risk for
such pathologies develops years before clinical symptoms appear, and is higher in people …

Type 2 Diabetes is a major public health threat, and its prevalence is increasing worldwide.
The abnormal accumulation of islet amyloid polypeptide (IAPP) in pancreatic β-cells is …

Background β-Cell death is the key feature of type 2 diabetes mellitus (T2DM). The
misfolding of human Islet Amyloid Polypeptide (hIAPP) is regarded as one of the causative …

The deposition of proteins in the form of insoluble amyloid fibril aggregates is linked to a
range of diseases. The supramolecular architecture of such deposits is governed by the …

It has become increasingly apparent that defective insulin signaling may increase the risk for
develo** Alzheimer's disease (AD), influence neurodegeneration through promotion of …