Apoptosis and apoptotic body: disease message and therapeutic target potentials

X Xu, Y Lai, ZC Hua - Bioscience reports, 2019 - portlandpress.com
Apoptosis is widely known as programmed cell death eliciting no inflammatory responses.
The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth …

Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

EÁ Tóth, L Turiák, T Visnovitz, C Cserép… - Journal of …, 2021 - Wiley Online Library
In this study we tested whether a protein corona is formed around extracellular vesicles
(EVs) in blood plasma. We isolated medium‐sized nascent EVs of THP1 cells as well as of …

Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake

ER Abels, XO Breakefield - Cellular and molecular neurobiology, 2016 - Springer
Extracellular vesicles are a heterogeneous group of membrane-limited vesicles loaded with
various proteins, lipids, and nucleic acids. Release of extracellular vesicles from its cell of …

Focus on extracellular vesicles: introducing the next small big thing

H Kalra, GPC Drummen, S Mathivanan - International journal of molecular …, 2016 - mdpi.com
Intercellular communication was long thought to be regulated exclusively through direct
contact between cells or via release of soluble molecules that transmit the signal by binding …

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

ML Merchant, IM Rood, JKJ Deegens… - Nature Reviews …, 2017 - nature.com
Urine is a valuable diagnostic medium and, with the discovery of urinary extracellular
vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed …

Biology and biogenesis of shed microvesicles

C Tricarico, J Clancy, C D'Souza-Schorey - Small GTPases, 2017 - Taylor & Francis
The ability of cells to transmit bioactive molecules to recipient cells and the extracellular
environment is a fundamental requirement for both normal physiology and disease …

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

BW Sódar, Á Kittel, K Pálóczi, KV Vukman… - Scientific reports, 2016 - nature.com
Circulating extracellular vesicles have emerged as potential new biomarkers in a wide
variety of diseases. Despite the increasing interest, their isolation and purification from body …

Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles

M Colombo, G Raposo, C Théry - Annual review of cell and …, 2014 - annualreviews.org
In the 1980s, exosomes were described as vesicles of endosomal origin secreted from
reticulocytes. Interest increased around these extracellular vesicles, as they appeared to …

[HTML][HTML] Extracellular/circulating microRNAs: release mechanisms, functions and challenges

MH Sohel - Achievements in the Life Sciences, 2016 - Elsevier
MicroRNAs (miRNAs) are endogenously initiated, small non-coding RNAs and typically
regulate the expression of mRNAs in post transcriptional level either via translational …