Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Mast cells are found resident in tissues throughout the body, particularly in association with
structures such as blood vessels and nerves, and in proximity to surfaces that interface the …

Mast cells (MCs) are constitutively present in most tissues and a distinct subset of MCs can
also be induced upon host responses to inflammation. The hematopoietic lineage …

This book lays out the principles of general pathology for biomedical researchers, grad
students, medical students, and physicians, with elegance and deep insight. Disease …

TUMOUR necrosis factor-α (TNF-α)/cachectin is a multifunctional cytokine that has effects in
inflammation, sepsis, lipid and protein metabolism, haematopoiesis, angiogenesis and host …

Mast cells have been recognized for well over 100 years. With time, human mast cells have
been documented to originate from CD34+ cells, and have been implicated in host …

We have cloned a partial cDNA encoding murine stem cell factor (SCF) and show that the
gene is syntenic with the SI locus on mouse chromosome 10. Using retroviral vectors to …

Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that have been implicated in
signal transduction through tyrosine kinase-and heterotrimeric G-protein-linked receptors …

The colony-stimulating factors (CSFs) are a group of cytokines central to the hematopoiesis
of blood cells, the modulation of their functional responses, as well as the maintenance of …

Materials and Methods Cell Lines. The HT2 mouse T cell line (17) was obtained from S.
Strober (Stanford University, Stanford, CA), the MC/9 mouse mast cell line (18) and D9 T cell …