In-line analysis of organ-on-chip systems with sensors: Integration, fabrication, challenges, and potential

S Fuchs, S Johansson, AØ Tjell, G Werr… - ACS Biomaterials …, 2021 - ACS Publications
Organ-on-chip systems are promising new in vitro research tools in medical,
pharmaceutical, and biological research. Their main benefit, compared to standard cell …

Technical feasibility and physiological relevance of hypoxic cell culture models

J Pavlacky, J Polak - Frontiers in endocrinology, 2020 - frontiersin.org
Hypoxia is characterized as insufficient oxygen delivery to tissues and cells in the body and
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …

3D printed HUVECs/MSCs cocultures impact cellular interactions and angiogenesis depending on cell-cell distance

C Piard, A Jeyaram, Y Liu, J Caccamese, SM Jay… - Biomaterials, 2019 - Elsevier
Vascularization is a crucial process during the growth and development of bone 1, yet it
remains one of the main challenges in the reconstruction of large bone defects. The use of in …

One‐step generation of core–shell gelatin methacrylate (GelMA) microgels using a droplet microfluidic system

H Wang, H Liu, H Liu, W Su, W Chen… - Advanced Materials …, 2019 - Wiley Online Library
Gelatin methacrylate (GelMA) microgels are promising scaffolds for biological applications,
such as tissue engineering and drug screening. Solid‐like GelMA microgels are limited by …

[HTML][HTML] Gut-on-Chip microphysiological systems: Latest advances in the integration of sensing strategies and adoption of mature detection mechanisms

MA Signore, C De Pascali, L Giampetruzzi… - Sensing and Bio …, 2021 - Elsevier
Synergic efforts in microfabrication processes, cells culture and tissue engineering promoted
extraordinary progress in Organ-on-Chip (OoC) technology, leading to the development of in …

Oxygen consumption rate of tumour spheroids during necrotic-like core formation

R Mukomoto, Y Nashimoto, T Terai, T Imaizumi… - Analyst, 2020 - pubs.rsc.org
Hypoxia is one of the major hallmarks of solid tumours and is associated with the poor
prognosis of various cancers. A multicellular aggregate, termed a spheroid, has been used …

The current landscape of 3D in vitro tumor models: what cancer hallmarks are accessible for drug discovery?

D Rodenhizer, T Dean, E D'Arcangelo… - Advanced …, 2018 - Wiley Online Library
Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis,
and personal genetics. While investment in research is at an all‐time high, new drugs are …

Think outside the box: 3D bioprinting concepts for biotechnological applications–recent developments and future perspectives

F Krujatz, S Dani, J Windisch, J Emmermacher… - Biotechnology …, 2022 - Elsevier
Abstract 3D bioprinting–the fabrication of geometrically complex 3D structures from
biocompatible materials containing living cells using additive manufacturing technologies–is …

Transcriptional landscape of 3D vs. 2D ovarian cancer cell models

R Kerslake, B Belay, S Panfilov, M Hall, I Kyrou… - Cancers, 2023 - mdpi.com
Simple Summary Ovarian cancer is one of the most lethal female cancers. Numerous
investigations into the development and progression of this disease have resulted in the …

Biosensors to monitor cell activity in 3D hydrogel-based tissue models

A Fedi, C Vitale, P Giannoni, G Caluori, A Marrella - Sensors, 2022 - mdpi.com
Three-dimensional (3D) culture models have gained relevant interest in tissue engineering
and drug discovery owing to their suitability to reproduce in vitro some key aspects of human …