BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …

As a major component of the human body, the extracellular matrix (ECM) is a complex
biopolymer network. The ECM not only hosts a plethora of biochemical interactions but also …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …

The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

The physical properties of two-dimensional (2D) extracellular matrices (ECMs) modulate cell
adhesion dynamics and motility, but little is known about the roles of local …

In this work, we constructed a Collagen I–Matrigel composite extracellular matrix (ECM). The
composite ECM was used to determine the influence of the local collagen fiber orientation …

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …