[HTML][HTML] Molecular mechanisms and applications of N-acyl homoserine lactone-mediated quorum sensing in bacteria

L Kumar, SKS Patel, K Kharga, R Kumar, P Kumar… - Molecules, 2022 - mdpi.com
Microbial biodiversity includes biotic and abiotic components that support all life forms by
adapting to environmental conditions. Climate change, pollution, human activity, and natural …

[HTML][HTML] Quorum quenching: a drug discovery approach against Pseudomonas aeruginosa

MA Rather, D Saha, S Bhuyan, AN Jha… - Microbiological …, 2022 - Elsevier
Pseudomonas aeruginosa, a ubiquitous opportunistic and nosocomial biofilm-forming
pathogen with complex, interconnected and hierarchical nature of QS systems (Las, Rhl …

In-silico homology assisted identification of inhibitor of RNA binding against 2019-nCoV N-protein (N terminal domain)

P Sarma, N Shekhar, M Prajapat, P Avti… - Journal of …, 2021 - Taylor & Francis
The N terminal domain (NTD) of Nucleocapsid protein (N protein) of coronavirus (CoV)
binds to the viral (+) sense RNA and results in CoV ribonucleoprotien (CoV RNP) complex …

Pseudomonas aeruginosa Biofilm Formation and Its Control

A Vetrivel, M Ramasamy, P Vetrivel, S Natchimuthu… - Biologics, 2021 - mdpi.com
Microbes are hardly seen as planktonic species and are most commonly found as biofilm
communities in cases of chronic infections. Biofilms are regarded as a biological condition …

Abiotic Small Molecule Inhibitors and Activators of the LasR Quorum Sensing Receptor in Pseudomonas aeruginosa with Potencies Comparable or Surpassing N …

DE Manson, GE Ananiev, S Guo… - ACS infectious …, 2024 - ACS Publications
The opportunistic pathogen Pseudomonas aeruginosa controls almost 10% of its genome,
including myriad virulence genes, via a cell-to-cell chemical communication system called …

Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis

MT Khayat, TS Ibrahim, KM Darwish, AN Khayyat… - Microorganisms, 2022 - mdpi.com
Bacteria communicate with each other using quorum sensing (QS) which works in an
inducer/receptor manner. QS plays the main role in orchestrating diverse bacterial virulence …

In vivo, in vitro and molecular docking studies reveal the anti-virulence property of hispidulin against Pseudomonas aeruginosa through the modulation of quorum …

VT Anju, S Busi, MS Mohan, S Ranganathan… - International …, 2022 - Elsevier
Pseudomonas aeruginosa is an audacious infectious agent involved in multiple persistent
and incurable diseases in hosts through quorum sensing mediated pathways. Thus …

[HTML][HTML] Virtual Screening of FDA-Approved Drugs against LasR of Pseudomonas aeruginosa for Antibiofilm Potential

S Sadiq, NF Rana, MA Zahid, MK Zargaham… - Molecules, 2020 - mdpi.com
Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is present
commonly in soil and water and is responsible for causing septic shock, pneumonia, urinary …

High-Throughput Virtual Screening for a New Class of Antagonist Targeting LasR of Pseudomonas aeruginosa

A Vetrivel, S Natchimuthu, V Subramanian… - ACS …, 2021 - ACS Publications
Pseudomonas aeruginosa, an opportunistic human pathogen, causes fatal effects in
patients with cystic fibrosis and immunocompromised individuals and leads to around 1000 …

Computational discovery of plant-based inhibitors against human carbonic anhydrase IX and molecular dynamics simulation

S Mahmud, E Rahman, Z Nain, M Billah… - Journal of …, 2021 - Taylor & Francis
Carbonic anhydrase IX (hCAIX) is a membrane-spanning metalloenzyme, encoded by CA9
gene, which can lead to various carcinomas if upregulated. Due to its overexpression in …