The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals
by activating fast-acting ligand-gated ion channels and more slowly acting G-protein …

Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

GABAB receptors are broadly expressed in the nervous system and have been implicated in
a wide variety of neurological and psychiatric disorders. The cloning of the first GABAB …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

Experience-dependent gene transcription is required for nervous system development and
function. However, the DNA regulatory elements that control this program of gene …

G-protein-coupled receptors (GPCRs) represent one of the largest gene families in the
animal genome. These receptors can be classified into several groups based on the …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors
activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different …