Social connection as a public health issue: the evidence and a systemic framework for prioritizing the “social” in social determinants of health

J Holt-Lunstad - Annual Review of Public Health, 2022 - annualreviews.org
There is growing interest in and renewed support for prioritizing social factors in public
health both in the USA and globally. While there are multiple widely recognized social …

Allostatic load and its impact on health: a systematic review

J Guidi, M Lucente, N Sonino, GA Fava - Psychotherapy and …, 2020 - karger.com
Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events.
It involves the interaction of different physiological systems at varying degrees of activity …

Family relationships and well-being

PA Thomas, H Liu, D Umberson - Innovation in aging, 2017 - academic.oup.com
Family relationships are enduring and consequential for well-being across the life course.
We discuss several types of family relationships—marital, intergenerational, and sibling ties …

Evaluation of social isolation, loneliness, and cardiovascular disease among older women in the US

NM Golaszewski, AZ LaCroix, JG Godino… - JAMA network …, 2022 - jamanetwork.com
Importance Social isolation and loneliness are increasing public health concerns and have
been associated with increased risk of cardiovascular disease (CVD) among older adults …

Associations between social isolation, loneliness, and objective physical activity in older men and women

S Schrempft, M Jackowska, M Hamer, A Steptoe - BMC public health, 2019 - Springer
Background The impact of social isolation and loneliness on health risk may be mediated by
a combination of direct biological processes and lifestyle factors. This study tested the …

Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus

JJ Joseph, SH Golden - Annals of the New York Academy of …, 2017 - Wiley Online Library
Controversy exists over the role of stress and depression in the pathophysiology of type 2
diabetes mellitus. Depression has been shown to increase the risk for progressive insulin …

The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity

SJ Lupien, RP Juster, C Raymond, MF Marin - Frontiers in …, 2018 - Elsevier
For the last five decades, science has managed to delineate the mechanisms by which
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …

Social relationships and physiological determinants of longevity across the human life span

YC Yang, C Boen, K Gerken, T Li… - Proceedings of the …, 2016 - National Acad Sciences
Two decades of research indicate causal associations between social relationships and
mortality, but important questions remain as to how social relationships affect health, when …

Loneliness, social isolation and risk of cardiovascular disease in the English Longitudinal Study of Ageing

NK Valtorta, M Kanaan, S Gilbody… - European journal of …, 2018 - academic.oup.com
Background There is increasing evidence of an association between social relationships
and morbidity in general, and cardiovascular disease in particular. However, recent …

Brain on stress: how the social environment gets under the skin

BS McEwen - Proceedings of the National Academy of …, 2012 - National Acad Sciences
Stress is a state of the mind, involving both brain and body as well as their interactions; it
differs among individuals and reflects not only major life events but also the conflicts and …