Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …

Damage to the central nervous system (CNS) elicits the activation of both astrocytes and
microglia. This review is focused on the principal features that characterize the activation of …

Microglia form a regularly spaced network of resident glial cells throughout the central
nervous system (CNS). They are morphologically, immunophenotypically and functionally …

Damage to the central nervous system (CNS) leads to cellular changes not only in the
affected neurons but also in adjacent glial cells and endothelia, and frequently, to a …

Microglia can be isolated with high purity but low yield by shaking off loosely adherent cells
from mixed glial cultures. Here we describe a new technique for isolating microglia with an …

Multiple sclerosis (MS) is thought to be an autoimmune disease. In healthy individuals, the T
cells of the immune system, when activated by an infectious agent, regularly traffic across an …

Microglia, which contribute substantially to the tumor mass of glioblastoma, have been
shown to play an important role in glioma growth and invasion. While a large number of …

Traumatic brain injury (TBI) has become the signature wound of wars in Afghanistan and
Iraq. Injury may result from a mechanical force, a rapid acceleration-deceleration movement …

The CSF-1 receptor (CSF-1R) regulates CNS microglial development. However, the
localization and developmental roles of this receptor and its ligands, IL-34 and CSF-1, in the …

Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell
death in many neurodegenerative diseases. How neurons die in these tauopathies is …