The challenge of large litters on the immune system of the sow and the piglets

C Oliviero, S Junnikkala… - … in Domestic Animals, 2019 - Wiley Online Library
The use of hyperprolific sow lines has increased litter size considerably in the last three
decades. Nowadays, in some countries litters can reach up to 18–20 piglets being a major …

Physiological alterations associated with intrauterine growth restriction in fetal pigs: causes and insights for nutritional optimization

J Wang, C Feng, T Liu, M Shi, G Wu… - Molecular …, 2017 - Wiley Online Library
Intrauterine growth restriction (IUGR) remains a major problem in swine production since the
associated low birth weight leads to high rates of pre‐weaning morbidity and mortality plus …

Offspring of hyper prolific sows: Immunity, birthweight, and heterogeneous litters

C Oliviero - Molecular Reproduction and Development, 2023 - Wiley Online Library
In Europe, in the last 3 decades, there has been a constant increase in litter size due to the
use of superior maternal line genetics. Those sows giving birth to more piglets than their …

Pregnancy in pigs: the journey of an early life

F Almeida, ALNA Dias - Domestic animal endocrinology, 2022 - Elsevier
Embryo mortality is responsible for greater losses in litter size in pigs. It is well known that
pregnancy establishment is a complex process, and important changes occur continuously …

Genetic selection against intrauterine growth retardation in piglets: a problem at the piglet level with a solution at the sow level

SM Matheson, GA Walling, SA Edwards - Genetics Selection Evolution, 2018 - Springer
Background In polytocous livestock species, litter size and offspring weight act
antagonistically; in modern pig breeds, selection for increased litter size has resulted in …

Heat stress-induced fetal intrauterine growth restriction is associated with elevated LPS levels along the maternal intestine–placenta–fetus Axis in pregnant mice

X Zheng, W Ma, Y Wang, C Wu, J Wang… - Journal of Agricultural …, 2023 - ACS Publications
The exacerbation of the greenhouse effect has made heat stress (HS) an important risk
factor for the occurrence of intrauterine growth restriction (IUGR). The experiment aims to …

Maternal supply of cysteamine alleviates oxidative stress and enhances angiogenesis in porcine placenta

S Huang, Z Wu, Z Huang, X Hao, L Zhang, C Hu… - Journal of Animal …, 2021 - Springer
Background Oxidative stress in placenta is associated with the occurrence of adverse
pregnancy outcomes in sow, but there are few satisfactory treatment strategies for these …

A maternal Western diet during gestation and lactation modifies offspring's microbiota activity, blood lipid levels, cognitive responses, and hippocampal neurogenesis …

D Val-Laillet, M Besson, S Guérin… - The FASEB …, 2017 - Wiley Online Library
ABSTRACT A suboptimal early nutritional environment (ie, excess of energy, sugar, and fat
intake) can increase susceptibility to diseases and neurocognitive disorders. The purpose of …

Controlled elevated temperatures during early-mid gestation cause placental insufficiency and implications for fetal growth in pregnant pigs

W Zhao, F Liu, AW Bell, HH Le, JJ Cottrell, BJ Leury… - Scientific Reports, 2020 - nature.com
It is known that pig offspring born from pregnant pigs exposed to elevated ambient
temperatures during gestation have altered phenotypes, possibly due to placental …

Fructose synthesis and transport at the uterine-placental interface of pigs: cell-specific localization of SLC2A5, SLC2A8, and components of the polyol pathway

CB Steinhauser, MK Landers, L Myatt… - Biology of …, 2016 - academic.oup.com
The fetal fluids and uterine flushings of pigs contain higher concentrations of fructose than
glucose, but fructose is not detected in maternal blood. Fructose can be synthesized from …