Multiple sclerosis and SARS-CoV-2: has the interplay started?

G Bellucci, V Rinaldi, MC Buscarinu, R Reniè… - Frontiers in …, 2021‏ - frontiersin.org
Current knowledge on Multiple Sclerosis (MS) etiopathogenesis encompasses complex
interactions between the host's genetic background and several environmental factors that …

[PDF][PDF] Multiple sclerosis and autoimmunity: a veiled relationship

Z Barkhane, J Elmadi, LS Kumar, LS Pugalenthi… - Cureus, 2022‏ - cureus.com
Multiple sclerosis (MS) is an autoimmune inflammatory illness that affects the central
nervous system (CNS) when the body's immune system attacks its tissue. It is characterized …

Genetic, transcriptome, proteomic, and epidemiological evidence for blood-brain barrier disruption and polymicrobial brain invasion as determinant factors in …

CJ Carter - Journal of Alzheimer's disease reports, 2017‏ - content.iospress.com
Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey
showed that AD genome-wide association study (GWAS) genes (localized in bone marrow …

Twin studies in multiple sclerosis: A meta-estimation of heritability and environmentality

C Fagnani, MC Neale, L Nisticò… - Multiple sclerosis …, 2015‏ - journals.sagepub.com
Background: Most twin studies of multiple sclerosis (MS) are inconclusive regarding the
impact of genes and environment on disease susceptibility. In particular, high uncertainty …

The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review

G Bellucci, A Albanese, C Rizzi, V Rinaldi… - Frontiers in …, 2023‏ - frontiersin.org
Interferon-beta (IFN-β) for Multiple Sclerosis (MS) is turning 30. The COVID-19 pandemic
rejuvenated the interest in interferon biology in health and disease, opening translational …

Epstein-Barr virus genetic variants are associated with multiple sclerosis

R Mechelli, C Manzari, C Policano, A Annese, E Picardi… - Neurology, 2015‏ - neurology.org
Objective: We analyzed the Epstein-Barr nuclear antigen 2 (EBNA2) gene, which contains
the most variable region of the viral genome, in persons with multiple sclerosis (MS) and …

Gene–environment interaction in autoimmune disease

JA Ellis, AS Kemp, AL Ponsonby - Expert Reviews in Molecular …, 2014‏ - cambridge.org
Autoimmune disease manifests in numerous forms, but as a disease group is relatively
common in the population. It is complex in aetiology, with genetic and environmental …

EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy

VAG Ricigliano, AE Handel, GK Sandve, V Annibali… - PLoS …, 2015‏ - journals.plos.org
Epstein-Barr virus (EBV) is a non-heritable factor that associates with multiple sclerosis
(MS). However its causal relationship with the disease is still unclear. The virus establishes …

A perspective of coagulation dysfunction in multiple sclerosis and in experimental allergic encephalomyelitis

D Plantone, M Inglese, M Salvetti… - Frontiers in …, 2019‏ - frontiersin.org
A key role of both coagulation and vascular thrombosis has been reported since the first
descriptions of multiple sclerosis (MS). Subsequently, the observation of a close …

Environmental and genetic factors in pediatric inflammatory demyelinating diseases

E Waubant, AL Ponsonby, M Pugliatti, H Hanwell… - Neurology, 2016‏ - neurology.org
The onset of multiple sclerosis (MS) occurs in childhood in about 5% of all patients with MS.
The disease in adults has a complex genetic and environmental inheritability. One of the …