▪ Abstract Viral envelope glycoproteins promote viral infection by mediating the fusion of the
viral membrane with the host-cell membrane. Structural and biochemical studies of two viral …

Exposure to blood-borne pathogens poses a serious risk to health care workers (HCWs). We
review the risk and management of human immunodeficiency virus (HIV), hepatitis B virus …

Importance New data and therapeutic options warrant updated recommendations for the use
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …

Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels,
indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist …

An 8-person subcommittee of the National Institute of Allergy and Infectious Diseases
(NIAID) Mycoses Study Group evaluated available data on the treatment of cryptococcal …

T-20, a synthetic peptide corresponding to a region of the transmembrane subunit of the HIV-
1 envelope protein, blocks cell fusion and viral entry at concentrations of less than 2 ng/ml in …

The need to stem the growing problem of antimicrobial resistance has prompted multiple,
sometimes conflicting, calls for changes in the use of antimicrobial agents. One source of …

New treatments for HIV can improve immune functioning and decrease mortality. However,
lapses in adherence may render these complex regimens ineffective. Sixty-three men and 9 …

The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …

OBJECTIVE: Adherence to complex antiretroviral therapy (ART) is critical for HIV treatment
but difficult to achieve. The development of interventions to improve adherence requires …