Mitochondria are functionally versatile organelles. In addition to their conventional role of
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …

The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce
chemotactic signals in phagocytes and mediate host-defense as well as inflammatory …

Interleukin‐8 (IL‐8) belongs to a family of small, structurally related cytokines similar to
platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to …

We report the cloning of a gene, intronless in its coding region, which we have named APJ.
This gene was cloned using the polymerase chain reaction (PCR), with a set of primers …

Publisher Summary This chapter focuses on interleukin-8 (IL-8) and related chemotactic
cytokines—namely, CXC and CC chemokines. IL-8 is the best known member of a new …

Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best
characterized activities of IL-8 include the chemoattraction and activation of neutrophils …

Flavocytochrome b 558 is the catalytic core of the respiratory-burst oxidase, an enzyme
complex that catalyzes the NADPH-dependent reduction of O 2 into the superoxide anion O …

A random primed expression cDNA library was constructed from the RNA of NG 108-15
cells. Pools of plasmid DNA were transfected into COS cells, which were screened for their …

Interleukin-8 (IL-8) is an inflammatory cytokine that activates neutrophil chemotaxis,
degranulation, and the respiratory burst. Neutrophils express receptors for IL-8 that are …

Leukocytes accumulate at sites of inflammation and microbial infection in direct response to
locally produced chemotactic factors, which signal through specific G protein-coupled …