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Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …
Phagocytosis: our current understanding of a universal biological process
Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm
in diameter, including microorganisms, foreign substances, and apoptotic cells …
in diameter, including microorganisms, foreign substances, and apoptotic cells …
The clearance of dead cells by efferocytosis
Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …
induced in a setting-dependent manner. As billions of cells die during mammalian …
Lipid metabolism in regulation of macrophage functions
J Yan, T Horng - Trends in cell biology, 2020 - cell.com
Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …
The cytoskeleton in phagocytosis and macropinocytosis
Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …
perform essential antimicrobial and homeostatic functions. These functions rely on the …
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis
Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in
large part by triggering macrophage phagocytosis of cancer cells,,,,,–. However, cancer cells …
large part by triggering macrophage phagocytosis of cancer cells,,,,,–. However, cancer cells …
Phagocytosis: a fundamental process in immunity
One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …
the first to observe the uptake of particles by cells and realized the importance of this …
Intracellular pathogens: host immunity and microbial persistence strategies
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …
are ranked as the second leading cause of death worldwide by the World Health …
Modulation of immune responses by particle size and shape
The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …
Phagocytosis in the brain: homeostasis and disease
Microglia are resident macrophages of the central nervous system and significantly
contribute to overall brain function by participating in phagocytosis during development …
contribute to overall brain function by participating in phagocytosis during development …