Ion mobility mass spectrometry (IM-MS) for structural biology: insights gained by measuring mass, charge, and collision cross section
E Christofi, P Barran - Chemical Reviews, 2023 - ACS Publications
The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …
MS) techniques has provided substantial insights into the field of structural biology over the …
Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis)
E Gaggelli, H Kozlowski, D Valensin… - Chemical …, 2006 - ACS Publications
Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …
Endothelial leakiness elicited by amyloid protein aggregation
Alzheimer's disease (AD) is a major cause of dementia debilitating the global ageing
population. Current understanding of the AD pathophysiology implicates the aggregation of …
population. Current understanding of the AD pathophysiology implicates the aggregation of …
Intrinsically disordered proteins from A to Z
VN Uversky - The international journal of biochemistry & cell biology, 2011 - Elsevier
The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
Ion mobility mass spectrometry of proteins and protein assemblies
C Uetrecht, RJ Rose, E van Duijn, K Lorenzen… - Chemical Society …, 2010 - pubs.rsc.org
Traditionally, mass spectrometry has been a powerful analytical method enabling the
structural analysis of small molecules, and later on peptides and proteins. With the advent of …
structural analysis of small molecules, and later on peptides and proteins. With the advent of …
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large
conformational space. Certain conformations lead to aggregation prone and non …
conformational space. Certain conformations lead to aggregation prone and non …
Adding a new separation dimension to MS and LC–MS: what is the utility of ion mobility spectrometry?
Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …
entails separating ions in the gas phase based on their size, shape, and charge. While ion …
How useful is ion mobility mass spectrometry for structural biology? The relationship between protein crystal structures and their collision cross sections in the gas …
E Jurneczko, PE Barran - Analyst, 2011 - pubs.rsc.org
The technique of ion mobility mass spectrometry (IM-MS) has become of increasing interest
for rapid analysis of the conformations adopted by biological macromolecules. It is currently …
for rapid analysis of the conformations adopted by biological macromolecules. It is currently …
Integration of mass spectrometry data for structural biology
Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of
proteins and the complexes they form with other macromolecules. There are now several …
proteins and the complexes they form with other macromolecules. There are now several …
Structural characterization of copper (II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease
The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other
neurodegenerative synucleinopathies. We demonstrate here that Cu (II) ions are effective in …
neurodegenerative synucleinopathies. We demonstrate here that Cu (II) ions are effective in …