The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …

Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial
enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types …

Microglia have been implicated in Alzheimer's disease (AD) pathogenesis through the
identification of risk factor genes that are specifically or predominantly expressed in this cell …

Transcription factor EB (TFEB) mediates gene expression through binding to the
coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include …

Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-
associated diseases. However, there are no scalable approaches to comprehensively …

Background Microglia regulate the response to injury and disease in the brain and spinal
cord. In white matter diseases microglia may cause demyelination. However, how microglia …

Neurodegenerative disorders have been extremely challenging to treat with traditional drug-
based approaches and curative therapies are lacking. Given continued progress in stem cell …

The central nervous system (CNS) is constantly surveilled by microglia, highly motile and
dynamic cells deputed to act as the first line of immune defense in the brain and spinal cord …

Cellular perturbations underlying Alzheimer's disease are primarily studied in human
postmortem samples and model organisms. Here we generated a single-nucleus atlas from …