Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
Emerging trends in cryo-EM-based structural studies of neuropathological amyloids
S Mishra - Journal of Molecular Biology, 2023 - Elsevier
Tauopathies, synucleinopathies, Aβ amyloidosis, TDP-43 proteinopathies, and prion
diseases-these neurodegenerative diseases have in common the formation of amyloid …
diseases-these neurodegenerative diseases have in common the formation of amyloid …
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation
α-Synuclein (aSyn) aggregation underlies neurodegenerative synucleinopathies. aSyn
seeds are proposed to replicate and propagate neuronal pathology like prions. Seeding of …
seeds are proposed to replicate and propagate neuronal pathology like prions. Seeding of …
[HTML][HTML] Deep learning-based structure modelling illuminates structure and function in uncharted regions of β-solenoid fold space
Repeat proteins are common in all domains of life and exhibit a wide range of functions. One
class of repeat protein contains solenoid folds where the repeating unit consists of β-strands …
class of repeat protein contains solenoid folds where the repeating unit consists of β-strands …
Multifaceted interactions mediated by intrinsically disordered regions play key roles in alpha synuclein aggregation
Abstract The aggregation of Alpha Synuclein (α-Syn) into fibrils is associated with the
pathology of several neurodegenerative diseases. Pathologic aggregates of α-Syn adopt …
pathology of several neurodegenerative diseases. Pathologic aggregates of α-Syn adopt …
On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
The aggregation of the protein α-synuclein is closely associated with several
neurodegenerative disorders and as such the structures of the amyloid fibril aggregates …
neurodegenerative disorders and as such the structures of the amyloid fibril aggregates …
Role of conformational dynamics in pathogenic protein aggregation
The accumulation of pathogenic protein oligomers and aggregates is associated with
several devastating amyloid diseases. As protein aggregation is a multi-step nucleation …
several devastating amyloid diseases. As protein aggregation is a multi-step nucleation …
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies
Like many neurodegenerative diseases, Parkinson's disease (PD) is characterized by the
formation of proteinaceous aggregates in brain cells. In PD, those proteinaceous aggregates …
formation of proteinaceous aggregates in brain cells. In PD, those proteinaceous aggregates …
Dopaminergic system and neurons: role in multiple neurological diseases
H Chen, J Li, Z Huang, X Fan, X Wang, X Chen… - …, 2024 - Elsevier
The dopaminergic system is a complex and powerful neurotransmitter system in the brain. It
plays an important regulatory role in motivation, reward, cognition, and motor control. In …
plays an important regulatory role in motivation, reward, cognition, and motor control. In …