Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and …

D Mokra, M Joskova, J Mokry - International journal of molecular sciences, 2022 - mdpi.com
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

Potential role of natural compounds as anti-angiogenic agents in cancer

MK Shanmugam, S Warrier, AP Kumar… - Current vascular …, 2017 - ingentaconnect.com
Background: Neovascularization, also known as angiogenesis, is the process of capillary
sprouting from pre-existing blood vessels. This physiological process is a hallmark event in …

Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy

M Mirza-Aghazadeh-Attari, EM Ekrami, SAM Aghdas… - Life sciences, 2020 - Elsevier
Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …

Antiangiogenic effect of flavonoids and chalcones: An update

L Mirossay, L Varinská, J Mojžiš - International journal of molecular …, 2017 - mdpi.com
Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones
are intensively investigated because of a large spectrum of their biological activities. Among …

Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants

P Viaña‐Mendieta, ML Sánchez… - International wound …, 2022 - Wiley Online Library
Wound healing is a complex process of communication between growth factors, reactive
species of oxygen, cells, signalling pathways, and cytokines in the extracellular matrix, in …

Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases

J Guo, K Li, Y Lin, Y Liu - Frontiers in Nutrition, 2023 - frontiersin.org
Aging is the most important factor contributing to cardiovascular diseases (CVDs), and the
incidence and severity of cardiovascular events tend to increase with age. Currently, CVD is …

Antiangiogenic phytochemicals constituent of diet as promising candidates for chemoprevention of cancer

AD Marrero, AR Quesada, B Martínez-Poveda… - Antioxidants, 2022 - mdpi.com
Despite the extensive knowledge on cancer nature acquired over the last years, the high
incidence of this disease evidences a need for new approaches that complement the clinical …

In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

K Saeki, S Hayakawa, S Nakano, S Ito, Y Oishi… - Molecules, 2018 - mdpi.com
Green tea has been shown to have beneficial effects on many diseases such as cancer,
obesity, inflammatory diseases, and neurodegenerative disorders. The major green tea …

[HTML][HTML] Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp …

H Tang, L Zeng, J Wang, X Zhang, Q Ruan, J Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract The effect of 5-fluorouracil (5-FU) chemotherapy for gastric cancer (GC) is limited by
drug-resistance. To conquer this drug-resistance, various treatments including combination …

Protective effect of epigallocatechin gallate on endothelial disorders in atherosclerosis

K Yamagata - Journal of Cardiovascular Pharmacology, 2020 - journals.lww.com
Healthy vascular endothelial cells regulate vascular tone and permeability, prevent vessel
wall inflammation, enhance thromboresistance, and contribute to general vascular health …