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Improving translation of animal models of addiction and relapse by reverse translation
Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …
animal models, including escalation of drug intake, punished drug seeking and taking …
Sex differences in opioid and psychostimulant craving and relapse: a critical review
A widely held dogma in the preclinical addiction field is that females are more vulnerable
than males to drug craving and relapse. Here, we first review clinical studies on sex …
than males to drug craving and relapse. Here, we first review clinical studies on sex …
Animal models of drug relapse and craving after voluntary abstinence: a review
Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …
several decades, this clinical scenario has been studied at the preclinical level using classic …
Opioid craving does not incubate over time in inpatient or outpatient treatment studies: Is the preclinical incubation of craving model lost in translation?
Within addiction science, incubation of craving is an operational label used to describe time-
dependent increases in drug seeking during periods of drug deprivation. The purpose of this …
dependent increases in drug seeking during periods of drug deprivation. The purpose of this …
The protective effect of social reward on opioid and psychostimulant reward and relapse: behavior, pharmacology, and brain regions
Until recently, most modern neuroscience research on addiction using animal models did
not incorporate manipulations of social factors. Social factors play a critical role in human …
not incorporate manipulations of social factors. Social factors play a critical role in human …
Factors modulating the incubation of drug and non-drug craving and their clinical implications
It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …
early abstinence and remains high during extended periods of time. Clinical evidence now …
Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats
Evidence indicates that the anterior (aIC), but not posterior (pIC), insular cortex promotes
cued reinstatement of cocaine seeking after extinction in rats. It is unknown whether these …
cued reinstatement of cocaine seeking after extinction in rats. It is unknown whether these …
Characterization of operant social interaction in rats: effects of access duration, effort, peer familiarity, housing conditions, and choice between social interaction vs …
Rationale and objective Social factors play a critical role in drug addiction. We recently
showed that rats will abstain from methamphetamine, cocaine, heroin, and remifentanil self …
showed that rats will abstain from methamphetamine, cocaine, heroin, and remifentanil self …
Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects
Modern society is reviving the practice of aromatherapy, and lavender is reported being the
most worldwide purchased plant for essential oil (EO) extraction. Since recent studies …
most worldwide purchased plant for essential oil (EO) extraction. Since recent studies …
Sex-and dose-dependent differences in the development of an addiction-like phenotype following extended-access fentanyl self-administration
Opioid use disorder (OUD) is a major epidemic in the United States, and fentanyl is a major
culprit. The National Institute on Drug Abuse has highlighted an urgent need for research on …
culprit. The National Institute on Drug Abuse has highlighted an urgent need for research on …