Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …

One of the defining features of the liver is the capacity to maintain a constant size despite
injury. Although the precise molecular signals involved in the maintenance of liver size are …

Hepatocellular carcinoma (HCC) typically has poor prognosis, because it is often diagnosed
at an advanced stage. Heterogeneous phenotypic and genetic traits of affected individuals …

Factors controlling the onset and progression of extracellular amyloid diseases remain
largely unknown. Central to disease etiology is the efficiency of the endoplasmic reticulum …

Genetic analysis, embryonic tissue explantation and in vivo chromatin studies have together
identified the distinct regulatory steps that are necessary for the development of endoderm …

During liver development, hepatoblasts differentiate into hepatocytes or biliary epithelial
cells (BEC). The BEC delineate the intrahepatic and extrahepatic bile ducts, and the …

The liver and pancreas arise from a common multipotent population of endoderm cells and
share many aspects of their early development. Yet each tissue originates from multiple …

The epithelial-to-mesenchymal transition (EMT) is a crucial process, occurring both during
development and tumor progression, by which an epithelial cell undergoes a conversion to …

Cytoglobin is a recently discovered vertebrate globin distantly related to myoglobin, and its
function is unknown. Here we present the first detailed analysis of the distribution and …

Fetal rat hepatocytes treated with transforming growth factor β (TGF-β) die by apoptosis.
However, a subpopulation of them survives and undergoes an epithelial mesenchymal …