Review of various NAMPT inhibitors for the treatment of cancer
Y Wei, H **ang, W Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the NAD
salvage pathway of mammalian cells and is overexpressed in numerous types of cancers …
salvage pathway of mammalian cells and is overexpressed in numerous types of cancers …
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer
D Sampath, TS Zabka, DL Misner, T O'Brien… - Pharmacology & …, 2015 - Elsevier
NAD is a metabolite that is an important cofactor and second messenger for a number of
cellular processes such as genomic stability and metabolism that are essential for survival …
cellular processes such as genomic stability and metabolism that are essential for survival …
Blocking non-enzymatic functions by PROTAC-mediated targeted protein degradation
D Sun, J Zhang, G Dong, S He… - Journal of Medicinal …, 2022 - ACS Publications
The non-enzymatic functions of target proteins play key roles in the regulation of various cell
signaling pathways and are closely related to numerous human diseases. However …
signaling pathways and are closely related to numerous human diseases. However …
Advances in NAD-lowering agents for cancer treatment
MS Ghanem, F Monacelli, A Nencioni - Nutrients, 2021 - mdpi.com
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …
NAD+ salvage pathway in cancer metabolism and therapy
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for various
physiological processes including energy metabolism, DNA repair, cell growth, and cell …
physiological processes including energy metabolism, DNA repair, cell growth, and cell …
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
X Zhu, H Liu, L Chen, C Wu, X Liu, Y Cang, B Jiang… - Cell Chemical …, 2022 - cell.com
Aberrant overexpression of nicotinamide phosphoribosyltransferase (NAMPT) has been
reported in a variety of tumor cells and is a poor prognosis factor for patient survival. It plays …
reported in a variety of tumor cells and is a poor prognosis factor for patient survival. It plays …
Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity
Abstract Changes in nicotinamide adenine dinucleotide (NAD+) levels that compromise
mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD+ …
mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD+ …
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
U Galli, C Travelli, A Massarotti… - Journal of medicinal …, 2013 - ACS Publications
Nicotinamide phoshophoribosyltransferase (NAMPT) plays a key role in the replenishment
of the NAD pool in cells. This in turn makes this enzyme an important player in bioenergetics …
of the NAD pool in cells. This in turn makes this enzyme an important player in bioenergetics …
Nicotinamide phosphoribosyltransferase in malignancy: a review
RE Shackelford, K Mayhall, NM Maxwell… - Genes & …, 2013 - journals.sagepub.com
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of
nicotinamide adenine dinucleotide (NAD) synthesis. Both intracellular and extracellular …
nicotinamide adenine dinucleotide (NAD) synthesis. Both intracellular and extracellular …
Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype
M Ohanna, M Cerezo, N Nottet, K Bille… - Genes & …, 2018 - genesdev.cshlp.org
Abstract In BRAF V600E melanoma cells, a global metabolomic analysis discloses a
decrease in nicotinamide adenine dinucleotide (NAD+) levels upon PLX4032 treatment that …
decrease in nicotinamide adenine dinucleotide (NAD+) levels upon PLX4032 treatment that …