Increased immune cell infiltration into tumors is associated with improved patient survival
and predicts response to immune therapies. Thus, identification of factors that determine the …

Immunotherapy has been recognized as an effective and important therapeutic modality for
multiple types of cancer. Nevertheless, it has been increasing recognized that clinical …

Tumor vasculature is characterized by aberrant structure and function, resulting in immune
suppressive profiles of tumor microenvironment (TME) through limiting immune cell …

Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …

Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of
tumors. Most mechanistic studies focus on their static functional status before or after …

Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in
antitumor immune response. However, certain immune cells can impair this response and …

Vessels that encapsulate tumour clusters (VETC) is a distinct histologic vascular pattern
associated with a novel mechanism of metastasis. First described in human cancers in 2004 …

Tumor cell extravasation across endothelial barrier has been recognized as a pivotal event
in orchestrating metastasis formation. This event is initiated by the interactions of …

Simple Summary Melanoma is the most aggressive and potentially lethal form of skin
cancer. Research over recent decades has highlighted the role of tumour vasculature in …

Although immunotherapy has improved the clinical treatment of lung adenocarcinoma
(LUAD), many tumors have poor responses to immunotherapy. In this study, we confirmed …