Paradigms of dynamic control of thyroid hormone signaling
Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …
Deiodinases and their intricate role in thyroid hormone homeostasis
C Luongo, M Dentice, D Salvatore - Nature Reviews Endocrinology, 2019 - nature.com
The deiodinase family of enzymes mediates the activation and inactivation of thyroid
hormone. The role of these enzymes in the regulation of the systemic concentrations of …
hormone. The role of these enzymes in the regulation of the systemic concentrations of …
Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement
Background: A number of recent advances in our understanding of thyroid physiology may
shed light on why some patients feel unwell while taking levothyroxine monotherapy. The …
shed light on why some patients feel unwell while taking levothyroxine monotherapy. The …
[HTML][HTML] Deiodinases and the three types of thyroid hormone deiodination reactions
L Sabatino, C Vassalle… - Endocrinology and …, 2021 - synapse.koreamed.org
Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity,
which both preserves the circulating levels of the biologically active triiodothyronine (T3) and …
which both preserves the circulating levels of the biologically active triiodothyronine (T3) and …
Hypertension in thyroid disorders
Arterial hypertension represents a major global health concern; more than one fourth of the
population is affected by high blood pressure. Albeit the underlying cause of the disease …
population is affected by high blood pressure. Albeit the underlying cause of the disease …
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling
B Gereben, AM Zavacki, S Ribich, BW Kim… - Endocrine …, 2008 - academic.oup.com
The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …
are critical for the biological effects mediated by thyroid hormone. Over the years, research …
Treatment with thyroid hormone
B Biondi, L Wartofsky - Endocrine reviews, 2014 - academic.oup.com
Thyroid hormone deficiency can have important repercussions. Treatment with thyroid
hormone in replacement doses is essential in patients with hypothyroidism. In this review …
hormone in replacement doses is essential in patients with hypothyroidism. In this review …
Deiodinases and the metabolic code for thyroid hormone action
Deiodinases modify the biological activity of thyroid hormone (TH) molecules, ie, they may
activate thyroxine (T4) to 3, 5, 3′-triiodothyronine (T3), or they may inactivate T3 to 3, 3 …
activate thyroxine (T4) to 3, 5, 3′-triiodothyronine (T3), or they may inactivate T3 to 3, 3 …
Combination Treatment with T4 and T3: Toward Personalized Replacement Therapy in Hypothyroidism?
B Biondi, L Wartofsky - The Journal of Clinical Endocrinology & …, 2012 - academic.oup.com
Context: Levothyroxine therapy is the traditional lifelong replacement therapy for hypothyroid
patients. Over the last several years, new evidence has led clinicians to evaluate the option …
patients. Over the last several years, new evidence has led clinicians to evaluate the option …
Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling
BACKGROUND: Thyroid hormone signaling is critical for development, growth and
metabolic control in vertebrates. Although serum concentration of thyroid hormone is …
metabolic control in vertebrates. Although serum concentration of thyroid hormone is …