KATP Channels in the Cardiovascular System

MN Foster, WA Coetzee - Physiological reviews, 2016‏ - journals.physiology.org
KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

[HTML][HTML] Electrophysiological properties of computational human ventricular cell action potential models under acute ischemic conditions

S Dutta, A Mincholé, TA Quinn, B Rodriguez - Progress in biophysics and …, 2017‏ - Elsevier
Acute myocardial ischemia is one of the main causes of sudden cardiac death. The
mechanisms have been investigated primarily in experimental and computational studies …

[HTML][HTML] Universal ventricular coordinates: A generic framework for describing position within the heart and transferring data

J Bayer, AJ Prassl, A Pashaei, JF Gomez… - Medical image …, 2018‏ - Elsevier
Being able to map a particular set of cardiac ventricles to a generic topologically equivalent
representation has many applications, including facilitating comparison of different hearts …

Role of abnormal repolarization in the mechanism of cardiac arrhythmia

OE Osadchii - Acta physiologica, 2017‏ - Wiley Online Library
In cardiac patients, life‐threatening tachyarrhythmia is often precipitated by abnormal
changes in ventricular repolarization and refractoriness. Repolarization abnormalities …

Exploring functional differences between the right and left ventricles to better understand right ventricular dysfunction

J Bernal-Ramirez, MC Díaz-Vesga… - Oxidative medicine …, 2021‏ - Wiley Online Library
The right and left ventricles have traditionally been studied as individual entities.
Furthermore, modifications found in diseased left ventricles are assumed to influence on …

Differences in left versus right ventricular electrophysiological properties in cardiac dysfunction and arrhythmogenesis

CE Molina, J Heijman, D Dobrev - … & electrophysiology review, 2016‏ - pmc.ncbi.nlm.nih.gov
A wide range of ion channels, transporters, signaling pathways and tissue structure at a
microscopic and macroscopic scale regulate the electrophysiological activity of the heart …

Dispersion of ventricular repolarization: Temporal and spatial

NV Arteyeva - World Journal of Cardiology, 2020‏ - pmc.ncbi.nlm.nih.gov
Repolarization heterogeneity (RH) is an intrinsic property of ventricular myocardium and the
reason for T-wave formation on electrocardiogram (ECG). Exceeding the physiologically …

Postrepolarization refractoriness in acute ischemia and after antiarrhythmic drug administration: action potential duration is not always an index of the refractory period

R Coronel, MJ Janse, T Opthof, AA Wilde, P Taggart - Heart rhythm, 2012‏ - Elsevier
Action potential duration is widely used as a measure of refractory period in ischemia.
Although the end of repolarization closely corresponds to the end of refractoriness in the …

Reduced Na+ current density underlies impaired propagation in the diabetic rabbit ventricle

CL Stables, H Musa, A Mitra, S Bhushal, M Deo… - Journal of molecular and …, 2014‏ - Elsevier
Diabetes is associated with an increased risk of sudden cardiac death, but the underlying
mechanisms remain unclear. Our goal was to investigate changes occurring in the action …

In Vivo Human Left-to-Right Ventricular Differences in Rate Adaptation Transiently Increase Pro-Arrhythmic Risk following Rate Acceleration

A Bueno-Orovio, BM Hanson, JS Gill, P Taggart… - PLoS …, 2012‏ - journals.plos.org
Left-to-right ventricular (LV/RV) differences in repolarization have been implicated in lethal
arrhythmias in animal models. Our goal is to quantify LV/RV differences in action potential …