Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

Phosphatidylinositol (PI) regulating enzymes are frequently altered in cancer and have
become a focus for drug development. Here, we explore the phosphatidylinositol-5 …

High-throughput screening identified 5 chemical analogs (termed the WX8-family) that
disrupted 3 events in lysosome homeostasis:(1) lysosome fission via tubulation without …

Regulatory T cells (Tregs) play fundamental roles in maintaining peripheral tolerance to
prevent autoimmunity and limit legitimate immune responses, a feature hijacked in tumor …

Genome-wide association studies identifying hundreds of susceptibility loci for autoimmune
diseases indicate that genes active in immune cells predominantly mediate risk. However …

While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P 2) in mammalian cells
is generated by the conversion of phosphatidylinositol-4-phosphate (PI-4-P) to PI-4, 5-P 2, a …

Cancer cells are challenged by a myriad of microenvironmental stresses, and it is their
ability to efficiently adapt to the constantly changing nutrient, energy, oxidative, and/or …

PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI-4, 5-P 2.
Distinct localization of phosphoinositides is fundamental for a multitude of cellular functions …

Most human cancer cells harbor loss-of-function mutations in the p53 tumor suppressor
gene. Genetic experiments have shown that phosphatidylinositol 5-phosphate 4-kinase α …