A wide array of molecular pathways has been investigated during the past decade in order
to understand the mechanisms by which the practice of physical exercise promotes …

The COVID-19 pandemic is an extraordinary global emergency that has led to the
implementation of unprecedented measures in order to stem the spread of the infection …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Background Persistent inflammation is involved in the pathogenesis of chronic diseases
such as type 2 diabetes mellitus (T2 DM) and cardiovascular disease (CVD). Aims The aim …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

Bone and skeletal muscle are integrated organs and their coupling has been considered
mainly a mechanical one in which bone serves as attachment site to muscle while muscle …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has
been linked to an elevated risk for many chronic diseases. The discovery of myokines …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …