Since its first clinical description (on his son) by William James West (1793–1848) in 1841,
and the definition of the classical triad of (1) infantile spasms;(2) hypsarrhythmia, and (3) …

Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose
significant challenges to the treating physician. Although an evidence‐based practice …

Objective: To update the 2004 American Academy of Neurology/Child Neurology Society
practice parameter on treatment of infantile spasms in children. Methods: MEDLINE and …

Children with infantile spasms are likely to have a poor outcome. Outcome measures for
infantile spasms include primary response to treatment, relapse of spasms, neurological …

The current spectrum of disorders associated to clinical spasms with onset in infancy is
wider than previously thought; accordingly, its terminology has changed. Nowadays, the …

Background Infantile spasms (West's Syndrome) is a syndrome that includes a peculiar type
of epileptic seizure—the spasms—and an electroencephalographic (EEG) abnormality often …

Inflammation is known to participate in the mediation of a growing number of acute and
chronic neurological disorders. Even so, the involvement of inflammation in the …

Tuberous sclerosis complex (TSC) is a congenital syndrome characterized by the
widespread development of benign tumors in multiple organs, caused by mutations in one of …

Purpose: In 2002, we reported our preliminary experience using the ketogenic diet (KD) for
predominantly intractable infantile spasms (IS) in 23 infants. Since that time, we have …