Phenols in pharmaceuticals: analysis of a recurring motif
Phenols and phenolic ethers are significant scaffolds recurring both in nature and among
approved small-molecule pharmaceuticals. This compendium presents the first …
approved small-molecule pharmaceuticals. This compendium presents the first …
Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use
A Skrzypczak-Wiercioch, K Sałat - Molecules, 2022 - mdpi.com
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its
consequences still remain a significant problem in medicine. Acute inflammatory responses …
consequences still remain a significant problem in medicine. Acute inflammatory responses …
Quantifying Parkinson's disease motor severity under uncertainty using MDS-UPDRS videos
Parkinson's disease (PD) is a brain disorder that primarily affects motor function, leading to
slow movement, tremor, and stiffness, as well as postural instability and difficulty with …
slow movement, tremor, and stiffness, as well as postural instability and difficulty with …
Pesticides and Parkinson's disease: Current and future perspective
Inappropriate use of pesticides has globally exposed mankind to a number of health
hazards. Still their production is rising at the rate of 11% annually and, has already …
hazards. Still their production is rising at the rate of 11% annually and, has already …
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease
A Dong, Y Yang, S Jiang, X Yao, D Qi, C Mao… - Acta Pharmacologica …, 2023 - nature.com
Inflammation is one of the pathogenic processes in Parkinson's disease (PD). Dopamine
receptor agonist pramipexole (PPX) is extensively used for PD treatment in clinics. A number …
receptor agonist pramipexole (PPX) is extensively used for PD treatment in clinics. A number …
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor
Dear Editor, Dopamine acts as an essential neurotransmitter whose signaling is conducted
through five G protein-coupled receptors (GPCRs), dopamine D1 to D5 receptors (DRD1 …
through five G protein-coupled receptors (GPCRs), dopamine D1 to D5 receptors (DRD1 …
A patent review on the current developments of benzoxazoles in drug discovery
The benzoxazole moiety is widely found in various natural compounds, which are often
found to be biologically active. Due to its versatile biological properties, benzoxazole has …
found to be biologically active. Due to its versatile biological properties, benzoxazole has …
Lipid-based nanocarriers for neurological disorders: a review of the state-of-the-art and therapeutic success to date
Neurodegenerative disorders including Alzheimer's, Parkinson's, and dementia are chronic
and advanced diseases that are associated with loss of neurons and other related …
and advanced diseases that are associated with loss of neurons and other related …
Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease
Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …
[HTML][HTML] Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced …
S Ahmed, MM El-Sayed, MA Kandeil… - Saudi Pharmaceutical …, 2022 - Elsevier
Abstract Sodium-glucose co-transporter 2 (SGLT 2) inhibitors are a relatively new
antidiabetic drug with antioxidant and anti-inflammatory properties. Therefore, this study …
antidiabetic drug with antioxidant and anti-inflammatory properties. Therefore, this study …