Organic Bioelectronics for In Vitro Systems

C Pitsalidis, AM Pappa, AJ Boys, Y Fu… - Chemical …, 2021 - ACS Publications
Bioelectronics have made strides in improving clinical diagnostics and precision medicine.
The potential of bioelectronics for bidirectional interfacing with biology through continuous …

Organ‐on‐a‐chip systems: microengineering to biomimic living systems

F Zheng, F Fu, Y Cheng, C Wang, Y Zhao, Z Gu - Small, 2016 - Wiley Online Library
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …

Recent progress in translational engineered in vitro models of the central nervous system

P Nikolakopoulou, R Rauti, D Voulgaris, I Shlomy… - Brain, 2020 - academic.oup.com
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Microphysiological human brain and neural systems-on-a-chip: potential alternatives to small animal models and emerging platforms for drug discovery and …

AP Haring, H Sontheimer, BN Johnson - Stem cell reviews and reports, 2017 - Springer
Translational challenges associated with reductionist modeling approaches, as well as
ethical concerns and economic implications of small animal testing, drive the need for …

Integrating organs-on-chips: multiplexing, scaling, vascularization, and innervation

DY Park, J Lee, JJ Chung, Y Jung, SH Kim - Trends in biotechnology, 2020 - cell.com
Organs-on-chips (OoCs) have attracted significant attention because they can be designed
to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to …

Functional connectivity in in vitro neuronal assemblies

D Poli, VP Pastore, P Massobrio - Frontiers in neural circuits, 2015 - frontiersin.org
Complex network topologies represent the necessary substrate to support complex brain
functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode …

Three‐dimensional models of the human brain development and diseases

M Jorfi, C D'Avanzo, DY Kim… - Advanced healthcare …, 2018 - Wiley Online Library
Deciphering the human brain pathophysiology remains one of the greatest challenges of the
21st century. Neurological disorders represent a significant proportion of diseases burden; …

The potential of in vitro neuronal networks cultured on micro electrode arrays for biomedical research

M Cerina, MC Piastra, M Frega - Progress in Biomedical …, 2023 - iopscience.iop.org
In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Modular microstructure design to build neuronal networks of defined functional connectivity

C Forró, G Thompson-Steckel, S Weaver… - Biosensors and …, 2018 - Elsevier
Theoretical and in vivo neuroscience research suggests that functional information transfer
within neuronal networks is influenced by circuit architecture. Due to the dynamic …