Modeling fragile X syndrome in the Fmr1 knockout mouse

TM Kazdoba, PT Leach, JL Silverman… - Intractable & rare …, 2014 - jstage.jst.go.jp
Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …

Phenotypic variation and FMRP levels in fragile X

DZ Loesch, RM Huggins… - Mental retardation and …, 2004 - Wiley Online Library
Data on the relationships between cognitive and physical phenotypes, and a deficit of fragile
X mental retardation 1 (FMR1) gene‐specific protein product, FMRP, are presented and …

[BOK][B] Neuroconstructivism-I: How the brain constructs cognition

D Mareschal, MH Johnson, S Sirois, M Spratling… - 2007 - books.google.com
What are the processes, from conception to adulthood, that enable a single cell to grow into
a sentient adult? The processes that occur along the way are so complex that any attempt to …

Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models

CL Gatto, K Broadie - Frontiers in synaptic neuroscience, 2010 - frontiersin.org
Proper brain function requires stringent balance of excitatory and inhibitory synapse
formation during neural circuit assembly. Mutation of genes that normally sculpt and …

Visuo-spatial ability in individuals with Down syndrome: Is it really a strength?

Y Yang, FA Conners, EC Merrill - Research in developmental disabilities, 2014 - Elsevier
Down syndrome (DS) is associated with extreme difficulty in verbal skills and relatively better
visuo-spatial skills. Indeed, visuo-spatial ability is often considered a strength in DS …

Visual search in typically develo** toddlers and toddlers with Fragile X or Williams syndrome

G Scerif, K Cornish, J Wilding, J Driver… - Developmental …, 2004 - Wiley Online Library
Visual selective attention is the ability to attend to relevant visual information and ignore
irrelevant stimuli. Little is known about its typical and atypical development in early …

A phenotypic and molecular characterization of the fmr1‐tm1Cgr Fragile X mouse

QJ Yan, PK Asafo‐Adjei, HM Arnold… - Genes, Brain and …, 2004 - Wiley Online Library
Fragile X Syndrome is the most common form of inherited mental retardation. It is also
known for having a substantial behavioral morbidity, including autistic features. In humans …

Tracing syndrome-specific trajectories of attention across the lifespan

K Cornish, G Scerif, A Karmiloff-Smith - Cortex, 2007 - Elsevier
This paper maintains that studies of atypical attention targeting one particular age group are
unlikely to be informative of syndrome-specific deficits and their developmental changes. We …

ADHD symptoms in children with FXS

K Sullivan, D Hatton, J Hammer… - American Journal of …, 2006 - Wiley Online Library
Parent‐and teacher‐report of attention‐deficit/hyperactivity disorder (ADHD) symptoms were
examined using problem behavior and DSM‐IV symptom inventory questionnaires for 63 …

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

D Gothelf, JA Furfaro, F Hoeft, MA Eckert… - Annals of Neurology …, 2008 - Wiley Online Library
Objective To determine how neuroanatomic variation in children and adolescents with
fragile X syndrome is linked to reduced levels of the fragile X mental retardation‐1 protein …