Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and
novel treatments are urgently needed. Current therapeutic approaches for diabetic …

Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed,
and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular …

Abstract Bax inhibitor-1 (BI1) conveys anti-apoptotic signals for mitochondria while prohibitin
2 (PHB2) is implicated in sustaining mitochondrial morphology and function. However, their …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by
the lack of almost any glomerular phenotype in patients with profound renal ischemia, we …

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …

Pathologic alterations in podocytes lead to failure of an essential component of the
glomerular filtration barrier and proteinuria in chronic kidney diseases. Elevated levels of …

In recent years, although the development of clinical therapy for diabetic kidney disease
(DKD) has made great progress, the progression of DKD still cannot be controlled …