This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …

Introduction Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) lower
cholesterol synthesis in patients with hypercholesterolemia. Increased statin exposure is an …

Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …

The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …

Simvastatin is among the most commonly used prescription medications for cholesterol
reduction. A single coding single‐nucleotide polymorphism, rs4149056T> C, in SLCO1B1 …

Statins are a cornerstone in the pharmacological prevention of cardiovascular disease.
Although generally well tolerated, a small subset of patients experience statin-related …

Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …

The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …