Age and DNA repair deficiencies are strong risk factors for develo** cancer. This is
reflected in the comorbidity of cancer with premature aging diseases associated with DNA …

Mitochondria plays privotal role in diverse pathways that regulate cellular function and
survival, and have emerged as a prime focus in aging and age-associated motor neuron …

Diabetic Retinopathy (DR) is one of the most important microvascular complications of
diabetes mellitus, which can lead to blindness in severe cases. Mitochondria are energy …

Background Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes,
is a major cause of vision loss among middle-aged people worldwide, and the number of …

The DNA damage response (DDR) consists of multiple specialized pathways that recognize
different insults sustained by DNA and repairs them where possible to avoid the …

In recent years, various AI-based methods have been developed in order to uncover
chemico-biological interactions associated with DNA damage and oxidative stress. Various …

DNA damage repair (DDR) proteins are well recognized as guardians of the genome that
are frequently lost during malignant transformation of normal cells across cancer types. To …

Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional
and molecularly targeted therapies. Despite its clinical relevance, the mechanisms …

Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment
of cancer cells without harming healthy cells and develo** cancer-specific drugs. The …

Mitochondria provide energy for all cellular processes, including reactions associated with
cell cycle progression, DNA damage repair, and cilia formation. Moreover, mitochondria …