Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
Complement activation, regulation, and molecular basis for complement‐related diseases
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …
becomes activated upon recognition of molecular patterns associated with microorganisms …
Complement and its receptors: new insights into human disease
VM Holers - Annual review of immunology, 2014 - annualreviews.org
Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …
architecture of the complement system has been known for decades. Two major roles of …
[HTML][HTML] Atypical hemolytic uremic syndrome
D Kavanagh, TH Goodship, A Richards - Seminars in nephrology, 2013 - Elsevier
Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia,
thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease …
thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease …
Atypical hemolytic uremic syndrome
C Loirat, V Frémeaux-Bacchi - Orphanet journal of rare diseases, 2011 - Springer
Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia,
thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin …
thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin …
Structural basis for sialic acid–mediated self-recognition by complement factor H
The serum protein complement factor H (FH) ensures downregulation of the complement
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …
Protection of host cells by complement regulators
The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …
protection from pathogen invasion but has also evolved to participate in physiological …
Dimerization of complement factor H-related proteins modulates complement activation in vivo
E Goicoechea de Jorge, JJE Caesar… - Proceedings of the …, 2013 - National Acad Sciences
The complement system is a key component regulation influences susceptibility to age-
related macular degeneration, meningitis, and kidney disease. Variation includes genomic …
related macular degeneration, meningitis, and kidney disease. Variation includes genomic …
Complement factor H in host defense and immune evasion
Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases
S Rodríguez de Córdoba - Immunological Reviews, 2023 - Wiley Online Library
The implementation of next‐generation sequencing technologies has provided a sharp
picture of the genetic variability in the components and regulators of the alternative pathway …
picture of the genetic variability in the components and regulators of the alternative pathway …