Cellular compartments and organelles organize biological matter. Most well-known
organelles are separated by a membrane boundary from their surrounding milieu. There are …

BACKGROUND Numerous lines of evidence challenge the traditional interpretations of how
crystals nucleate and grow in synthetic and natural systems. In contrast to the monomer-by …

The assembly of conjugated organic molecules from solution to solid-state plays a critical
role in determining the thin film morphology and optoelectronic properties of solution …

Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …

Phase transitions driven by intrinsically disordered protein regions (IDRs) have emerged as
a ubiquitous mechanism for assembling liquid-like RNA/protein (RNP) bodies and other …

Many proteins contain disordered regions of low-sequence complexity, which cause aging-
associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like …

Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …

Many cellular proteins demix spontaneously from solution to form liquid condensates. These
phase-separated structures have wide-ranging roles in health and disease. Elucidating the …

RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein
aggregates or through phase separation into a liquid RNA/protein phase. Which model …

Exciting recent developments suggest that phase transitions represent an important and
ubiquitous mechanism underlying intracellular organization. We describe key experimental …