Bakuchiol–a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches

TPA Krishna, B Edachery, S Athalathil - RSC advances, 2022 - pubs.rsc.org
Bakuchiol is an emblematic meroterpene class of natural product extracted from Psoralea
corylifolia. It has been reported to possess a broad range of biological and pharmacological …

Deploying microbial synthesis for halogenating and diversifying medicinal alkaloid scaffolds

SA Bradley, J Zhang, MK Jensen - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Plants produce some of the most potent therapeutics and have been used for thousands of
years to treat human diseases. Today, many medicinal natural products are still extracted …

Synthesis and Evaluation of Bakuchiol Derivatives as Potent Anti-inflammatory Agents in Vitro and in Vivo

Q Ma, M Bian, G Gong, C Bai, C Liu, C Wei… - Journal of Natural …, 2022 - ACS Publications
Bakuchiol, a prenylated phenolic monoterpene derived from the fruit of Psoralen corylifolia
L.(Buguzhi), is widely used to treat tumors, viruses, inflammation, and bacterial infections. In …

Chemical Predictive Modelling and Natural Product‐based Divergent Synthesis–Design of Type B PPAPs with Nanomolar Activities against MRSA

P Peslalz, A Vorbach, A Bleisch… - … A European Journal, 2024 - Wiley Online Library
In response to the pressing global challenge of antibiotic resistance, time efficient design
and synthesis of novel antibiotics are of immense need. Polycyclic polyprenylated …

Synthesis and biological studies of (+)-liquiditerpenoic acid A (abietopinoic acid) and representative analogues: SAR studies

D Hamulic, M Stadler, S Hering… - Journal of natural …, 2019 - ACS Publications
The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-
liquiditerpenoic acid A (abietopinoic acid)(7) along with several analogues are reported. The …

Recent advances in the chemistry and biology of bakuchiol and its derivatives: An updated review

N Gupta, PL Sangwan, R Shankar… - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Bakuchiol is a meroterpene natural product distributed in various plants. It possesses
several biological activities particularly anticancer. A large number of analogs have been …

Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells

E Beeby, M Magalhães, MFL Lemos, IM Pires… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance The past few years have witnessed an increasing interest
in essential oils (EOs) as potential therapeutic agents against a wide variety of pathologies …

Synthesis and anti-proliferative evaluation of novel 3, 4-dihydro-2 H-1, 3-oxazine derivatives of bakuchiol

N Gupta, S Sharma, A Raina, NA Dangroo… - RSC …, 2016 - pubs.rsc.org
A new series of 3, 4-dihydro-2H-1, 3-oxazine derivatives of bakuchiol 1 was synthesized
through the Mannich-type condensation–cyclization reaction of 1 with formaldehyde and …

Bakuchiol targets mitochondrial proteins, prohibitins and voltage-dependent anion channels: New insights into develo** antiviral agents

M Shoji, T Esumi, T Masuda, N Tanaka… - Journal of Biological …, 2024 - ASBMB
We previously reported that bakuchiol, a phenolic isoprenoid anticancer compound, and its
analogs exert anti-influenza activity. However, the proteins targeted by bakuchiol remain …

Bakuchiol: A potential anticancer compound from Psoralea corylifolia linn

B Chopra, AK Dhingra, AS Grewal… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Background: Bakuchiol is a monoterpene phenol isolated from the seeds of Psoralea
corylifolia Linn. It is used traditionally in Indian and Chinese medicine and has been …