Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …

This review aims to synthesise a large pre-clinical and clinical literature related to a
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …

Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …

The midbrain dopamine system is a sophisticated hub that integrates diverse inputs to
control multiple physiological functions, including locomotion, motivation, cognition, reward …

There is strong comorbidity between chronic pain and depression, although the neural
circuits and mechanisms underlying this association remain unclear. By combining …

Dopamine and its receptors are currently recognized targets for the treatment of several
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …