Oral squamous cell carcinomas: state of the field and emerging directions

Y Tan, Z Wang, M Xu, B Li, Z Huang, S Qin… - International journal of …, 2023‏ - nature.com
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Q Shi, C Xue, Y Zeng, X Yuan, Q Chu, S Jiang… - … and Targeted Therapy, 2024‏ - nature.com
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …

CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers

R Bill, P Wirapati, M Messemaker, W Roh, B Zitti… - Science, 2023‏ - science.org
Tumor microenvironments (TMEs) influence cancer progression but are complex and often
differ between patients. Considering that microenvironment variations may reveal rules …

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

M Lechner, J Liu, L Masterson, TR Fenton - Nature reviews Clinical …, 2022‏ - nature.com
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology

T Chu, Z Wang, D Pe'er, CG Danko - Nature cancer, 2022‏ - nature.com
Inferring single-cell compositions and their contributions to global gene expression changes
from bulk RNA sequencing (RNA-seq) datasets is a major challenge in oncology. Here we …

Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

A Chamoli, AS Gosavi, UP Shirwadkar, KV Wangdale… - Oral oncology, 2021‏ - Elsevier
Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral
cavity. The substantial risk factors for OCSCC are the consumption of tobacco products …

Head and neck squamous cell carcinoma

DE Johnson, B Burtness, CR Leemans… - Nature reviews Disease …, 2020‏ - nature.com
Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …

PI3K inhibitors are finally coming of age

B Vanhaesebroeck, MWD Perry, JR Brown… - Nature reviews Drug …, 2021‏ - nature.com
Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

JL Vos, JBW Elbers, O Krijgsman, JJH Traets… - Nature …, 2021‏ - nature.com
Surgery for locoregionally advanced head and neck squamous cell carcinoma (HNSCC)
results in 30‒50% five-year overall survival. In IMCISION (NCT03003637), a non …

RAS-targeted therapies: is the undruggable drugged?

AR Moore, SC Rosenberg, F McCormick… - Nature reviews Drug …, 2020‏ - nature.com
Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …