The emergence of high‐throughput technologies for the comprehensive measurement of
biomolecules, also referred to as “omics” technologies, has helped us gather “big data” and …

Dental caries, a prevalent global infectious condition affecting over 95% of adults, remains
elusive in its precise etiology. Addressing the complex dynamics of caries demands a …

Background Dental calculus, calcified oral plaque biofilm, contains microbial and host
biomolecules that can be used to study historic microbiome communities and host …

Major advances over the past decade in the field of ancient DNA are providing access to
past paleogenomic diversity, but the diverse functions and biosynthetic capabilities of this …

The prevalence of chronic, non-communicable diseases has risen sharply in recent
decades, especially in industrialized countries. While several studies implicate the …

State-of-the-art proteomics software routinely quantifies thousands of peptides per
experiment with minimal need for manual validation or processing of data. For the emerging …

Dental calculus (calcified dental plaque) is prevalent in archaeological skeletal collections
and is a rich source of oral microbiome and host-derived ancient biomolecules. Recently, it …

Background Dental calculus (mineralised dental plaque) preserves many types of
microfossils and biomolecules, including microbial and host DNA, and ancient calculus are …

Mineralized dental plaque (calculus) has proven to be an excellent source of ancient
biomolecules. Here we present a Mycobacterium leprae genome (6.6-fold), the causative …

Following the discovery in the late 1980s that hard tissues such as bones and teeth preserve
genetic information, the field of ancient DNA analysis has typically concentrated upon these …