Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
A Sancar, LA Lindsey-Boltz… - Annual review of …, 2004 - annualreviews.org
▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …
Molecular mechanisms of ultraviolet radiation‐induced DNA damage and repair
RP Rastogi, null Richa, A Kumar… - Journal of nucleic …, 2010 - Wiley Online Library
DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …
Nucleotide excision repair in eukaryotes
OD Schärer - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky
DNA lesions such as those formed by UV light, environmental mutagens, and some cancer …
DNA lesions such as those formed by UV light, environmental mutagens, and some cancer …
DNA damage and associated DNA repair defects in disease and premature aging
Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
Molecular mechanisms of mammalian global genome nucleotide excision repair
Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …
Mechanisms of human DNA repair: an update
M Christmann, MT Tomicic, WP Roos, B Kaina - Toxicology, 2003 - Elsevier
The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …
[HTML][HTML] The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation
Summary The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of
cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects …
cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects …
p53: traffic cop at the crossroads of DNA repair and recombination
S Sengupta, CC Harris - Nature reviews Molecular cell biology, 2005 - nature.com
Abstract p53 mutants that lack DNA-binding activities, and therefore, transcriptional
activities, are among the most common mutations in human cancer. Recently, a new role for …
activities, are among the most common mutations in human cancer. Recently, a new role for …
Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
JE Cleaver, ET Lam, I Revet - Nature Reviews Genetics, 2009 - nature.com
Mutations in genes on the nucleotide excision repair pathway are associated with diseases,
such as xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy, that involve …
such as xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy, that involve …