In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Radiotherapy is used in the treatment of approximately 50% of all malignancies including
gastrointestinal cancers. Radiation can be given prior to surgery (neoadjuvant radiotherapy) …

This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

The number of deaths from colorectal cancer in Japan continues to increase. Colorectal
cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of …

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer
address diagnosis, staging, surgical management, perioperative treatment, management of …

PURPOSE In the multicenter, open-label, phase III FOWARC trial, modified infusional
fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus radiotherapy resulted in a higher …

Japanese mortality due to colorectal cancer is on the rise, surpassing 49,000 in 2015. Many
new treatment methods have been developed during recent decades. The Japanese …

Background Systemic relapses remain a major problem in locally advanced rectal cancer.
Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal …

Background Preoperative chemoradiotherapy with infusional fluorouracil, total mesorectal
excision surgery, and postoperative chemotherapy with fluorouracil was established by the …

Background Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision is
widely accepted as the standard of care for high-risk rectal cancer. Adjuvant chemotherapy …