Congenital long QT syndrome (LQTS) encompasses a group of heritable conditions that are
associated with cardiac repolarization dysfunction. Since its initial description in 1957, our …

The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

Endothelial dysfunction is one of the earliest manifestations of atherosclerosis, contributing
to its development and progression. Mental stress induces endothelial dysfunction through …

Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many
drugs from the market and is therefore of major concern to global regulatory agencies and …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …

Background—The current proarrhythmia safety testing paradigm, although highly efficient in
preventing new torsadogenic drugs from entering the market, has important limitations that …

Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …

Ventricular arrhythmias have complex causes and mechanisms. Despite extensive
investigation involving many clinical, experimental, and computational studies, effective …

Early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs) are voltage
oscillations known to cause cardiac arrhythmias. EADs are mainly driven by voltage …