Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Remodeling of large and small arteries contributes to the development and complications of
hypertension. The focus of this review is some of the mechanisms involved in the …

Abnormalities of resistance arteries may play a role in the pathogenesis and
pathophysiology of hypertension in experimental animals and humans. Vessels that, when …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

Significance: The vascular extracellular matrix (ECM) not only provides mechanical stability
but also manipulates vascular cell behaviors, which are crucial for vascular function and …

Accumulating evidence supports the importance of redox signaling in the pathogenesis and
progression of hypertension. Redox signaling is implicated in many different physiological …

Endothelin-1 (ET-1) is overexpressed in the vascular wall in certain models of experimental
hypertension: deoxycorticosterone acetate salt–treated rats, deoxycorticosterone acetate …

The very potent endogenous vasoconstrictor endothelin was discovered in 1988. We know
now that there are three isoforms (1, 2, and 3) and two receptor subtypes (A and B). A whole …