Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Cocaine use continues to be a serious worldwide public health problem. Cocaine abuse is
associated with substantial morbidity and mortality. Cocaine overdose deaths are increasing …

Importance In the US and the United Kingdom, cocaine use is the second leading cause of
illicit drug overdose death. Psychosocial treatments for cocaine use disorder are limited, and …

Background Despite widespread implementation of compulsory treatment modalities for
drug dependence, there has been no systematic evaluation of the scientific evidence on the …

Rationale Agonist-based pharmacologic intervention is an accepted approach in treatment
of opioid and tobacco use disorders. Objectives We conducted a systematic review and …

This review summarizes evidence of dysregulated reward circuitry function in a range of
neurodevelopmental and psychiatric disorders and genetic syndromes. First, the …

Most psychostimulants interact with monoamine transport proteins. This paper reviews work
our laboratory has conducted to investigate the interaction of psychostimulants with …

Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

Methamphetamine dependence is a serious worldwide public health problem with major
medical, psychiatric, socioeconomic and legal consequences. Various neuronal …

Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …