Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - Signal transduction and …, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Glial cells in schizophrenia: a unified hypothesis

AG Dietz, SA Goldman, M Nedergaard - The Lancet Psychiatry, 2020 - thelancet.com
The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …

[HTML][HTML] The gut–brain axis in schizophrenia: The implications of the gut microbiome and SCFA production

S Ju, Y Shin, S Han, J Kwon, TG Choi, I Kang, SS Kim - Nutrients, 2023 - mdpi.com
Schizophrenia, a severe mental illness affecting about 1% of the population, manifests
during young adulthood, leading to abnormal mental function and behavior. Its multifactorial …

Emerging evidence for astrocyte dysfunction in schizophrenia

EC de Oliveira Figueiredo, C Calì, F Petrelli, P Bezzi - Glia, 2022 - Wiley Online Library
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

[HTML][HTML] Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors

S Pittolo, S Yokoyama, DD Willoughby, CR Taylor… - Cell reports, 2022 - cell.com
The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly
influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters …

Neuron-glia networks: integral gear of brain function

G Perea, M Sur, A Araque - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Astrocytes, the most abundant glial cell in the brain, play critical roles in metabolic and
homeostatic functions of the Nervous System; however, their participation in coding …

Astrocyte regulation of synaptic signaling in psychiatric disorders

A Kruyer, PW Kalivas, MD Scofield - Neuropsychopharmacology, 2023 - nature.com
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in sha** neuronal synaptic activity and along with the pre-and …

Do stars govern our actions? Astrocyte involvement in rodent behavior

JF Oliveira, VM Sardinha, S Guerra-Gomes… - Trends in …, 2015 - cell.com
Astrocytes have emerged as important partners of neurons in information processing.
Important progress has been made in the past two decades in understanding the role of …

Modeling working memory in a spiking neuron network accompanied by astrocytes

SY Gordleeva, YA Tsybina, MI Krivonosov… - Frontiers in Cellular …, 2021 - frontiersin.org
We propose a novel biologically plausible computational model of working memory (WM)
implemented by a spiking neuron network (SNN) interacting with a network of astrocytes …

Astrocytes as new targets to improve cognitive functions

G Dallérac, N Rouach - Progress in neurobiology, 2016 - Elsevier
Astrocytes are now viewed as key elements of brain wiring as well as neuronal
communication. Indeed, they not only bridge the gap between metabolic supplies by blood …