Recent advances in the development of anti-infective peptoids

KL Bicker, SL Cobb - Chemical Communications, 2020 - pubs.rsc.org
In the search for new sources of antimicrobials many researchers have investigated
antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics …

Natural and synthetic peptides with antifungal activity

T Ciociola, L Giovati, S Conti, W Magliani… - Future medicinal …, 2016 - Taylor & Francis
In recent years, the increase of invasive fungal infections and the emergence of antifungal
resistance stressed the need for new antifungal drugs. Peptides have shown to be good …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

Hydroxyl containing benzo [b] thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle

B Haridevamuthu, T Manjunathan, A Guru, RS Kumar… - Life Sciences, 2022 - Elsevier
Aims This study aims to elucidate a systematic free-radical quenching ability of synthesized
benzo [b] thiophene derivatives using in vitro assays and acrylamide induced oxidatively …

Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model

A Guru, C Lite, AJ Freddy, PK Issac… - Developmental & …, 2021 - Elsevier
Antioxidant peptides are naturally present in food, especially in fishes, and are considered to
contain rich source of various bioactive compounds that are structurally heterogeneous. This …

[HTML][HTML] Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo …

N Prabha, A Guru, R Harikrishnan, MK Gatasheh… - Journal of King Saud …, 2022 - Elsevier
Oxidative stress causes disruption of cell macromolecules and resulting neurodegeneration
when the antioxidant defense mechanism is inhibited. Oxidative stress is emerging as a key …

A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents

ML Huang, SBY Shin, MA Benson, VJ Torres… - …, 2012 - Wiley Online Library
We investigated the antimicrobial activities of N‐substituted glycine “peptoid” oligomers
incorporating cationic and hydrophobic side chains. Head‐to‐tail macrocyclization was …

Furan based synthetic chalcone derivative functions against gut inflammation and oxidative stress demonstrated in in-vivo zebrafish model

SPRR Nayak, LS Dhivya, R Reshma… - European Journal of …, 2023 - Elsevier
Abstract Inflammatory Bowel Disease (IBD) is a group of persistent intestinal illnesses
resulting from bowel inflammation unrelated to infection. The prevalence of IBD is rising in …

Recent advances in the synthesis of peptoid macrocycles

AM Webster, SL Cobb - Chemistry–A European Journal, 2018 - Wiley Online Library
Over the past two decades, develo** medical applications for peptides has, and continues
to be a highly active area of research. At present there are over 60 peptide‐based drugs on …

A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids

CEM Salvador, B Pieber, PM Neu… - The Journal of …, 2015 - ACS Publications
The development of a continuous flow multistep strategy for the synthesis of linear peptoids
and their subsequent macrocyclization via Click chemistry is described. The central …