Recent advances in the development of anti-infective peptoids
In the search for new sources of antimicrobials many researchers have investigated
antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics …
antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics …
Natural and synthetic peptides with antifungal activity
T Ciociola, L Giovati, S Conti, W Magliani… - Future medicinal …, 2016 - Taylor & Francis
In recent years, the increase of invasive fungal infections and the emergence of antifungal
resistance stressed the need for new antifungal drugs. Peptides have shown to be good …
resistance stressed the need for new antifungal drugs. Peptides have shown to be good …
Peptoid polymers: a highly designable bioinspired material
J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …
advantages over their natural counterparts: the ability to precisely tune their structures over a …
Hydroxyl containing benzo [b] thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle
Aims This study aims to elucidate a systematic free-radical quenching ability of synthesized
benzo [b] thiophene derivatives using in vitro assays and acrylamide induced oxidatively …
benzo [b] thiophene derivatives using in vitro assays and acrylamide induced oxidatively …
Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model
Antioxidant peptides are naturally present in food, especially in fishes, and are considered to
contain rich source of various bioactive compounds that are structurally heterogeneous. This …
contain rich source of various bioactive compounds that are structurally heterogeneous. This …
[HTML][HTML] Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo …
Oxidative stress causes disruption of cell macromolecules and resulting neurodegeneration
when the antioxidant defense mechanism is inhibited. Oxidative stress is emerging as a key …
when the antioxidant defense mechanism is inhibited. Oxidative stress is emerging as a key …
A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents
We investigated the antimicrobial activities of N‐substituted glycine “peptoid” oligomers
incorporating cationic and hydrophobic side chains. Head‐to‐tail macrocyclization was …
incorporating cationic and hydrophobic side chains. Head‐to‐tail macrocyclization was …
Furan based synthetic chalcone derivative functions against gut inflammation and oxidative stress demonstrated in in-vivo zebrafish model
Abstract Inflammatory Bowel Disease (IBD) is a group of persistent intestinal illnesses
resulting from bowel inflammation unrelated to infection. The prevalence of IBD is rising in …
resulting from bowel inflammation unrelated to infection. The prevalence of IBD is rising in …
Recent advances in the synthesis of peptoid macrocycles
AM Webster, SL Cobb - Chemistry–A European Journal, 2018 - Wiley Online Library
Over the past two decades, develo** medical applications for peptides has, and continues
to be a highly active area of research. At present there are over 60 peptide‐based drugs on …
to be a highly active area of research. At present there are over 60 peptide‐based drugs on …
A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids
CEM Salvador, B Pieber, PM Neu… - The Journal of …, 2015 - ACS Publications
The development of a continuous flow multistep strategy for the synthesis of linear peptoids
and their subsequent macrocyclization via Click chemistry is described. The central …
and their subsequent macrocyclization via Click chemistry is described. The central …