Previous studies have shown that uptake of the lipophilic opioid, fentanyl, by pulmonary
endothelial cells occurs by both passive diffusion and carrier-mediated processes. To …

We present a model of gas exchange for hyperpolarized 129Xe in the lung, which we refer
to as the Model of Xenon Exchange. The model consists of two expressions and …

The microcirculation, integratively speaking, is distensible and contains 40%–50% of the
total blood volume. Other than the mission of mass transport, the microcirculation and its …

The multiple indicator dilution (MID) technique is often used for investigation of the kinetic
behavior of substrates and metabolites in eliminating organs. The present study was a …

It has been known for some time that regional blood flows within an organ are not uniform.
Useful measures of heterogeneity of regional blood flows are the standard deviation and …

Background Differences in the pharmacokinetics of the enantiomers of ketamine have been
reported. The authors sought to determine whether these differences extend to pulmonary …

P-Glycoprotein (P-gp) is an ATP-dependent drug efflux transporter involved in multidrug
resistance and drug disposition in many organ systems. A majority of P-gp substrates are …

The gamma and Erlang density functions describe a large class of lagged, right-skewed
distributions. The Erlang distribution has been shown to be the analytic solution for a chain …

The objective was to evaluate the pulmonary disposition of the ubiquinone homolog
coenzyme Q1 (CoQ1) on passage through lungs of normoxic (exposed to room air) and …

The lungs can substantially influence the redox status of redox-active plasma constituents.
Our objective was to examine aspects of the kinetics and mechanisms that determine …